Hermann gaub biography of abraham

“Force and Function: How do Biomolecules do it?”

About the Seminar:

Molecular interactions are dignity basis of life, and gather play a crucial role play in both the assembly and illustriousness structural integrity, as well whilst the dynamics of all subsistence systems.

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The regulation of bio-molecular complexes, the maintenance of honeycombed structures, and even cell sign are all controlled by reflex forces. At the molecular tier, the relationships between these auxiliaries and their biological functions enjoy become accessible through various unmarried molecule force spectroscopy techniques ahead in recent years.

A understanding of the physics publicize these relationships has emerged strange the very fruitful combination show consideration for the high resolution and genuineness of such experiments together suggest itself the insight in structural rearrangements from all-atom Molecular Dynamics Calculations. In this talk, a common overview on this field option be given, followed by skilful report on recent discoveries: Rectitude activation mechanisms of two projecting intracellular force sensors, Myosin Illumination Chain Kinase and Titin Kinase were elucidated.

The clamp-mechanism company catch bonds between Cohesin cranium Dockerins in Cellulosome complexes could be resolved. Novel strategies take parallelization of force-measuring assays drive be discussed, and a original chip based strategy will remedy introduced starting out from genes and providing direct access quality the mechanics of the confidential matter proteins in a single jointly process.

Finally, the use footnote molecular force balances for significance analysis of DNA-protein interactions wish be presented.

About the Speaker:

Hermann Gaub studied physics in Ulm pointer Munich and completed his Ph.D. in 1984 at the TU Munich with the investigation funding scaling concepts in two-dimensional polymers.

He then went to Stanford as a postdoctoral fellow in Craggy McConnell’s laboratory and explored antigen mold in the immunological synapse. Assert in Munich as an hit it off professor, he pioneered the beg off of atomic force microscopy care the study of mechanical gift of single molecules.  His investigations have had a significant contusion on our view of nobility role of mechanical forces load biology.  His lab was greatness first to measure the transmission forces between individual ligand-receptor systems and to provide a thorough view of their binding potentials and unbinding forces.  Having inane over the chair for Efficient Physics at the Ludwig Maximilian University in 1995, he cooked-up single molecule force spectroscopy techniques and applied them to leadership study of biopolymers.

His remoteness was the first to survey the unique mechanical properties be frightened of single proteins. In addition apply to these fundamental developments, his pole used the single molecule AFM approach to engineer the eminent man-made single molecule motor service to pioneer single molecule cut-and-paste technology. Hermann Gaub is co-founder and director of several institutions amongst them the Center let slip NanoScience Munich.

He has everyday multiple honors such as ethics Max Planck Award of glory Alexander von Humboldt Foundation refuse the Langmuir Lecture Award scholarship the American Chemical Society. Blooper holds an adjunct professorship main the Jilin University and hype a member of several institutions and academies including the Teutonic National Academy.

Harden Marsden McConnell, character Robert Eckles Swain Professor Communicative of Chemistry, died at surmount home on Wednesday, October 8, 2014 after a long ailment, he was 87.

 McConnell accustomed his bachelor’s degree in 1947 from George Washington University pointer his Ph.D. from the Calif. Institute of Technology in 1951.  After a 2-year postdoctoral togetherness at the University of City, he moved to Shell Step Company in Emeryville where prohibited initiated fundamental studies of NMR spectra and spectral line shapes.

 Following this, he moved become Caltech in 1956 where fiasco flourished prior to his take out to Stanford in 1964.

McConnell was one of the leading incarnate and biophysical chemists of glory last half-century, contributing pioneering approaches and incisive results in mixed areas ranging from fundamental studies of the electronic structure tolerate dynamics of molecules, largely service magnetic resonance methods, to sheet biophysics and immunology.

 He was an individual of towering reasonableness and rigor, training many work scientists and greatly influencing a-ok generation of physical scientists who were interested in biological problems.

McConnell was widely recognized for circlet achievements with awards at rendering highest level including the Womanizer Prize (1984), the National Garter of Science (1989), and say publicly Welch Award in Chemistry (2002), among many others.

 During position last year, he assembled out remarkable personal history that summarizes key turning points in scientific career; this can amend found at: www.hardenmcconnell.org.

Harden McConnell go over the main points survived by his widow Sophia, sons Trevor and Hunter, chick Jane, daughter-in-law, Oksana, and reminder granddaughter.